TARGET SPECIES: Chickens and turkeys.
INDICATION: The product is recommended for chickens and turkeys for the treatment and metaph of enteric inf. caused by non-invasive E. coli bact susceptible to colistin. Before starting the metaph treatment the presence of the disease in the herd must be confirmed.
100 ml of product contain:
Active substance
Colistin sulf.............................…..............….2,5 mil. U.I.
Vit A palmitate ..........................................1,0 mil. U.I.
Vit D3 .........................................................0,1 mil. U.I.
Vit E ..................................................................400 U.I.
Vit B1 ................................................................250 mg
Vit B6 ................................................................250 mg
Excipients
Met parahydroxybenz ..............................100 mg
Propyl parahydroxybenz ..................................20 mg
CONTRAINDICATIONS:
Do not use in horses, especially in foals, because colistin alters the balance of the gastrointestinal tract microflora and could lead to development of colitis associated with antimicrob administration (colitis X), usually associated with Clostridium difficile, which can be lethal.
ADVERSE REACTIONS:
They were not reported.
ADMINISTRATION:
The product is administered in the drinking water, in a dose of 10 ml/liter of water, for three consecutive days.
RECOMMENDATIONS FOR PROPER ADMINISTRATION:
The intake of medicated water depends on the clinical condition of the birds. In order to obtain the recommended dose, the product concentration should
be adjusted correctly. The duration of treatment should be limited to the minimum time necessary to treat the disease. The duration of treatment should not exceed 7 days.
OVERDOSE:
Colistin sulph should not be overdosed as it may cause nephrotox The recommended dose should be observed.
SPECIAL WARNINGS FOR EACH TARGET SPECIES:
Colistin has a concentration-dependent action against Gram-negative bact. Following oral administration, high concentrations are obtained
in the gastrointest tract, i.e. the target site, due to the insufficient absorption of the substance.
These factors indicate that a longer treatment than indicated, leading to unnecessary exposure, is not recommended.
USE DURING THE GESTATION, LACTATION OR LAYING PERIOD:
It may be administered during the laying period.
INTERACTIONS WITH OTHER MEDICINAL PRODUCTS OR OTHER FORMS OF INTERACTION:
The co-administration of other veterinary medicinal products containing bivalent metal ions should be avoided. The action of colistin on the germs of Pseudomon spp. is amplified in the presence of sulfamet, sulfamet and sulfacet. Thiamine hydrochl forms precipitates with iodine, tan acd and ammon ferric citrate; it is incompatible with alkaline solutions , with sugar solutions (glucose, lactose), with alcohol and gelatin. Pyrid hydrochl is incompatible with alkaline substances; for a pH above 5.0, the solution intensifies its color. It is inactivated by oxidants.
WITHDRAWAL PERIOD:
Meat and offal: zero days
Eggs: zero days
STORAGE:
Keep at a temperature not exceeding 25°C. Keep away from light.
SHELF LIFE:
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the primary packaging: 3 months.
Shelf life after dilution or reconstitution as instructed: 24 hours